Contraindicated (1)pentobarbital will reduce the extent or outcome of cariprazine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. CYP3A4 is liable for the development and elimination of cariprazine's Lively metabolites.pentobarbital will lower the level or effect of meloxicam by impacting hepatic enzyme CYP2C9/ten metabol